Smoking is not to blame for PAD4 antibody development in patients with RA

Erika Darrah and colleagues in the Johns Hopkins Arthritis Center found that, although smoking is linked to the development of RA and specific immune responses to proteins in the body, smoking is not responsible for the development of immune responses to a related protein, PAD4. The study was featured on the Johns Hopkins Rheumatology website.

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Cappelli LC, Konig MF, Gelber AC, Bingham CO 3rd, Darrah E. Smoking is not linked to the development of anti-peptidylarginine deiminase 4 autoantibodies in rheumatoid arthritis. Arthritis Res Ther. 2018 Mar 23;20(1):59.

doi: 10.1186/s13075-018-1533-z.
PMID: 29566742; PMCID: PMC5865363.