Publications
Get the full list of publications here.
2022
Gómez-Bañuelos E, Shi J, Wang H, Danila MI, Bridges SL Jr, Giles JT, Sims GP, Andrade F, Darrah E. Heavy chain constant region usage in antibodies to peptidylarginine deiminase 4 distinguishes disease subsets in rheumatoid arthritis. Arthritis Rheumatol. 2022 Jun 8.
doi: 10.1002/art.42262.
PMID: 35675168.
Moosic KB, Ananth K, Andrade F, Feith DJ, Darrah E, Loughran TP Jr. Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis. Front Oncol. 2022 May 13;12:869205.
doi: 10.3389/fonc.2022.869205
PMID: 35646651; PMCID: PMC9136414
Cappelli LC, Darrah E, Shah AA, Bingham CO. Patients with checkpoint inhibitor-induced inflammatory arthritis do not become seropositive for anti-cyclic citrullinated peptide when followed over time. ACR Open Rheumatol. 2022 Jan;4(1):83-84.
doi: 10.1002/acr2.11363
PMID: 34757698; PMCID: PMC8754020.
2021
Tiniakou E, Crawford J, Darrah E. Insights into origins and specificities of autoantibodies in systemic sclerosis. Curr Opin Rheumatol. 2021 Nov 1;33(6):486-494.
doi: 10.1097/BOR.0000000000000834
PMID: 34506340
Antiochos B, Paz M, Li J, Goldman DW, Petri M, Darrah E, Cashman K, Sanz I, Burns KH, Ardeljan D, Andrade F, Rosen A. Autoantibodies targeting LINE-1-encoded ORF1p are associated with systemic lupus erythematosus diagnosis but not disease activity. Clin Exp Rheumatol. 2021 Oct 13.
doi: 10.55563/clinexprheumatol/bfz387
PMID: 34665712
Román-Meléndez GD, Monaco DR, Montagne JM, Quizon RS, Konig MF, Astatke M, Darrah E, Larman HB. Citrullination of a phage-displayed human peptidome library reveals the fine specificities of rheumatoid arthritis-associated autoantibodies. EBioMedicine. 2021 Sep 1;71:103506.
doi: 10.1016/j.ebiom.2021.103506.
PMID: 34481243; PMCID: PMC8414044
Demoruelle MK, Wang H, Davis RL, Visser A, Hoang J, Norris JM, Holers VM, Deane KD, Darrah E. Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis. Arthritis Res Ther. 2021 Jun 6;23(1):163.
doi: 10.1186/s13075-021-02528-5.
PMID: 34092252; PMCID: PMC8182933
2020
Gutierrez-Hoffmann MG, O'Meally RN, Cole RN, Tiniakou E, Darrah E, Soloski MJ. Borrelia burgdorferi-Induced Changes in the Class II Self-Immunopeptidome Displayed on HLA-DR Molecules Expressed by Dendritic Cells. Front Med (Lausanne). 2020 Sep 16;7:568.
doi: 10.3389/fmed.2020.00568.
PMID: 33043033; PMCID: PMC7524959
Darrah E, Davis RL, Curran AM, Naik P, Chen R, Na CH, Giles JT, Andrade F. Citrulline Not a Major Determinant in the Recognition of Peptidylarginine Deiminase 2 and 4 by Autoantibodies in Rheumatoid Arthritis. Arthritis Rheumatol. 2020 Sep;72(9):1476-1482.
doi: 10.1002/art.41276.
PMID: 32255561; PMCID: PMC7541452.
Tiniakou E, Fava A, McMahan ZH, Guhr T, O'Meally RN, Shah AA, Wigley FM, Cole RN, Boin F, Darrah E. Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. Arthritis Rheumatol. 2020 Aug;72(8):1375-1384.
doi: 10.1002/art.41248.
PMID: 32162841; PMCID: PMC7486267.
Curran AM, Naik P, Giles JT, Darrah E. PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets. Nat Rev Rheumatol. 2020 Jun;16(6):301-315.
doi: 10.1038/s41584-020-0409-1.
PMID: 32341463.
Fert-Bober J, Darrah E, Andrade F. Insights into the study and origin of the citrullinome in rheumatoid arthritis. Immunol Rev. 2020 Mar;294(1):133-147.
doi: 10.1111/imr.12834.
PMID: 31876028.
Romero V, Darrah E, Andrade F. Generation of Distinct Patterns of Rheumatoid Arthritis Autoantigens by Peptidylarginine Deiminase Types 2 and 4 During Perforin-Induced Cell Damage. Arthritis Rheumatol. 2020 Jun;72(6):912-918.
doi: 10.1002/art.41196.
PMID: 31876120; PMCID: PMC7255925.
Cappelli LC, Thomas MA, Bingham CO 3rd, Shah AA, Darrah E. Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis. Immunol Rev. 2020 Mar;294(1):106-123.
doi: 10.1111/imr.12832.
PMID: 31930524; PMCID: PMC7047521.
2019
Gómez-Bañuelos E, Mukherjee A, Darrah E, Andrade F. Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J Clin Med. 2019 Aug 26;8(9):1309.
doi: 10.3390/jcm8091309.
PMID: 31454946; PMCID: PMC6780899.
Gutierrez MJ, Desiderio SV, Wang NY, Darrah E, Cappelli L, Nino G, Jones M, Bingham CO 3rd. Soluble Markers of Antibody Secreting Cell Function as Predictors of Infection Risk in Rheumatoid Arthritis. J Immunol Res. 2019 Apr 28;2019:3658215.
doi: 10.1155/2019/3658215.
PMID: 31183387; PMCID: PMC6512050.
Darrah E, Yu F, Cappelli LC, Rosen A, O'Dell JR, Mikuls TR. Association of Baseline Peptidylarginine Deiminase 4 Autoantibodies With Favorable Response to Treatment Escalation in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 May;71(5):696-702.
doi: 10.1002/art.40791.
PMID: 30507066; PMCID: PMC6483822.
Darrah E, Martinez-Prat L, Mahler M. Clinical Utility of Antipeptidyl Arginine Deiminase Type 4 Antibodies. J Rheumatol. 2019 Mar;46(3):329-330.
doi: 10.3899/jrheum.180905.
PMID: 30647163.
2018
Darrah E, Giles JT, Davis RL, Naik P, Wang H, Konig MF, Cappelli LC, Bingham CO 3rd, Danoff SK, Andrade F. Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis. Front Immunol. 2018 Nov 20;9:2696.
doi: 10.3389/fimmu.2018.02696.
PMID: 30515171; PMCID: PMC6255931.
Cappelli LC, Konig MF, Gelber AC, Bingham CO 3rd, Darrah E. Smoking is not linked to the development of anti-peptidylarginine deiminase 4 autoantibodies in rheumatoid arthritis. Arthritis Res Ther. 2018 Mar 23;20(1):59.
doi: 10.1186/s13075-018-1533-z.
PMID: 29566742; PMCID: PMC5865363.
Darrah E, Andrade F. Rheumatoid arthritis and citrullination. Curr Opin Rheumatol. 2018 Jan;30(1):72-78.
doi: 10.1097/BOR.0000000000000452.
PMID: 28937414; PMCID: PMC5848217.
Shi J, Darrah E, Sims GP, Mustelin T, Sampson K, Konig MF, Bingham CO 3rd, Rosen A, Andrade F. Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis. Ann Rheum Dis. 2018 Jan;77(1):141-148.
doi: 10.1136/annrheumdis-2017-211489.
PMID: 29070531; PMCID: PMC5935255.
2017
Zhou Y, Chen B, Mittereder N, Chaerkady R, Strain M, An LL, Rahman S, Ma W, Low CP, Chan D, Neal F, Bingham CO 3rd, Sampson K, Darrah E, Siegel RM, Hasni S, Andrade F, Vousden KA, Mustelin T, Sims GP. Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils. Front Immunol. 2017 Sep 25;8:1200.
doi: 10.3389/fimmu.2017.01200.
PMID: 28993780; PMCID: PMC5622307.
Kim A, Boronina TN, Cole RN, Darrah E, Sadegh-Nasseri S. Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen During Antigen-Processing. Sci Rep. 2017 Apr 19;7:46418.
doi: 10.1038/srep46418.
PMID: 28422163; PMCID: PMC5396073.
Navarro-Millán I, Darrah E, Westfall AO, Mikuls TR, Reynolds RJ, Danila MI, Curtis JR; CLEAR Investigators, Rosen A, Bridges SL Jr. Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans. Arthritis Res Ther. 2016 Oct 22;18(1):241.
doi: 10.1186/s13075-016-1126-7.
PMID: 27770831; PMCID: PMC5075170.
Darrah E, Kim A, Zhang X, Boronina T, Cole RN, Fava A, Giles JT, Bingham III CO, Chalmers MJ, Griffin PR, Sadegh-Nasseri S, Rosen A. Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis. J Proteome Res. 2017 Jan 6;16(1):355-365.
doi: 10.1021/acs.jproteome.6b00617.
PMID: 27700100; PMCID: PMC5218978.
2016
Seaman A, Darrah E, Infantino M, Meacci F, Manfredi M, Benucci M, Mahler M. Anti-peptidyl-arginine deaminase 3 (PAD3) antibodies as a promising marker to measure joint damage in patients with rheumatoid arthritis. Autoimmun Rev. 2016 Jul;15(7):776-80.
doi: 10.1016/j.autrev.2016.03.016.
PMID: 26997641.
2015
Darrah E, Andrade F. Editorial: citrullination, and carbamylation, and malondialdehyde-acetaldehyde! Oh my! Entering the forest of autoantigen modifications in rheumatoid arthritis. Arthritis Rheumatol. 2015 Mar;67(3):604-8.
doi: 10.1002/art.38970.
PMID: 25469991.
2014
Konig MF, Darrah E, Andrade F. Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: comment on the article by Shelef et al. Arthritis Rheumatol. 2014 Sep;66(9):2642-4.
doi: 10.1002/art.38719.
PMID: 24891314.
Giles JT, Darrah E, Danoff S, Johnson C, Andrade F, Rosen A, Bathon JM. Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease. PLoS One. 2014 Jun 5;9(6):e98794.
doi: 10.1371/journal.pone.0098794.
PMID: 24901704; PMCID: PMC4047055.
Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, Boin F, Fava A, Thoburn C, Kinde I, Jiao Y, Papadopoulos N, Kinzler KW, Vogelstein B, Rosen A. Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science. 2014 Jan 10;343(6167):152-7.
doi: 10.1126/science.1246886.
PMID: 24310608; PMCID: PMC4038033.
2013
Ferucci ED, Darrah E, Smolik I, Choromanski TL, Robinson DB, Newkirk MM, Fritzler MJ, Rosen A, El-Gabalawy HS. Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American Populations. J Rheumatol. 2013 Sep;40(9):1523-8.
doi: 10.3899/jrheum.130293.
PMID: 23908443; PMCID: PMC3969032.
Darrah E, Giles JT, Ols ML, Bull HG, Andrade F, Rosen A. Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity. Sci Transl Med. 2013 May 22;5(186):186ra65.
doi: 10.1126/scitranslmed.3005370.
PMID: 23698378; PMCID: PMC3740946.
Darrah E, Andrade F. NETs: the missing link between cell death and systemic autoimmune diseases? Front Immunol. 2013 Jan 17;3:428.
doi: 10.3389/fimmu.2012.00428.
PMID: 23335928; PMCID: PMC3547286.
Darrah E, Rosen A, Giles JT, Andrade F. Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis. Ann Rheum Dis. 2012 Jan;71(1):92-8.
doi: 10.1136/ard.2011.151712.
PMID: 21859690; PMCID: PMC3302156.
2010 and earlier
Kolfenbach JR, Deane KD, Derber LA, O'Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis Rheum. 2010 Sep;62(9):2633-9.
doi: 10.1002/art.27570.
PMID: 20496417; PMCID: PMC2946499.
Andrade F, Darrah E, Gucek M, Cole RN, Rosen A, Zhu X. Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. Arthritis Rheum. 2010 Jun;62(6):1630-40.
doi: 10.1002/art.27439.
PMID: 20201080; PMCID: PMC2951335.
Darrah E, Rosen A. Granzyme B cleavage of autoantigens in autoimmunity. Cell Death Differ. 2010 Apr;17(4):624-32.
doi: 10.1038/cdd.2009.197.
PMID: 20075942; PMCID: PMC3136751.
Harris ML, Darrah E, Lam GK, Bartlett SJ, Giles JT, Grant AV, Gao P, Scott WW Jr, El-Gabalawy H, Casciola-Rosen L, Barnes KC, Bathon JM, Rosen A. Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis. Arthritis Rheum. 2008 Jul;58(7):1958-67.
doi: 10.1002/art.23596.
PMID: 18576335; PMCID: PMC2692635.
Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11094-9.
doi: 10.1073/pnas.0501770102.
PMID: 16043714; PMCID: PMC1182417.